Lymphocyte Activation Gene - 3 ( CD 223 ) Negative Regulation of T Cell Homeostasis
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منابع مشابه
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).
Lymphocyte homeostasis is a central biological process that is tightly regulated. However, its molecular and cellular control is poorly understood. We show that aged mice deficient in lymphocyte activation gene 3 (LAG-3), an MHC class II binding CD4 homologue, have twice as many T cells as wild-type controls. CD4(+) and CD8(+) LAG-3-deficient T cells showed enhanced homeostatic expansion in lym...
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تاریخ انتشار 2004